Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Cullin 1. AA range:727-776
Subcellular Location
nucleoplasm,cytosol,SCF ubiquitin ligase complex,cullin-RING ubiquitin ligase complex,Parkin-FBXW7-Cul1 ubiquitin ligase complex,
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
8454
Observed Band
90kD
Other Name
CUL-1
CUL1
Cullin-1
CUL1
Cullin-1
Background
function:Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF c
protein ubiquitination.,PTM:Neddylated
the interaction seems to be mediated by FBXW8.,pathway:Protein modification
which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.,similarity:Belongs to the cullin family.,subunit:Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes
protein ubiquitination.,PTM:Neddylated
the interaction seems to be mediated by FBXW8.,pathway:Protein modification
which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.,similarity:Belongs to the cullin family.,subunit:Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes