Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human CHEK2. AA range:35-84
Subcellular Location
Nucleus, PML body. Nucleus, nucleoplasm. Recruited into PML bodies together with TP53.
[Isoform 2]: Nucleus. Isoform 10 is present throughout the cell.
[Isoform 4]: Nucleus.
[Isoform 7]: Nucleus.
[Isoform 9]: Nucleus.
[Isoform 12]: Nucleus.
[Isoform 2]: Nucleus. Isoform 10 is present throughout the cell.
[Isoform 4]: Nucleus.
[Isoform 7]: Nucleus.
[Isoform 9]: Nucleus.
[Isoform 12]: Nucleus.
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
11200
Observed Band
61kD
Other Name
CDS1
CHEK2
CHK2
CHK2 checkpoint homolog
Cds1 homolog
Checkpoint kinase 2
Hucds1
RAD53
Serine/threonine-protein kinase Chk2
hCds1
CHEK2
CHK2
CHK2 checkpoint homolog
Cds1 homolog
Checkpoint kinase 2
Hucds1
RAD53
Serine/threonine-protein kinase Chk2
hCds1
Background
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a fo