Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human ATF6B. AA range:401-450
Subcellular Location
Endoplasmic reticulum membrane
Single-pass type II membrane protein .
[Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. .
Single-pass type II membrane protein .
[Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
1388
Observed Band
90kD
Other Name
ATF6-beta
ATF6B
Activating transcription factor 6 beta
CREBL1
Cyclic AMP-dependent transcription factor ATF-6 beta
G13
Protein G13
cAMP-dependent transcription factor ATF-6 beta
cAMP response element-binding protein-related protein
ATF6B
Activating transcription factor 6 beta
CREBL1
Cyclic AMP-dependent transcription factor ATF-6 beta
G13
Protein G13
cAMP-dependent transcription factor ATF-6 beta
cAMP response element-binding protein-related protein
Background
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting
however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],
however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],