Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Aquaporin 2. AA range:222-271
Subcellular Location
Apical cell membrane
Multi-pass membrane protein . Basolateral cell membrane
Multi-pass membrane protein . Cell membrane
Multi-pass membrane protein . Cytoplasmic vesicle membrane
Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane
Multi-pass membrane protein . Shuttles from vesicles to the apical membrane (PubMed:15509592). Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane (PubMed:15509592). PLEKHA8/FAPP2 is required to transport AQP2 f
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Dog
Human
Monkey
Mouse
Rat
Human Gen
359
Observed Band
29kD
Other Name
ADH water channel
AQP-2
AQP-CD
AQP2
Aquaporin-2
Aquaporin-CD
Collecting duct water channel protein
WCH-CD
Water channel protein for renal collecting duct
Background
This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and