Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human c-Abl. AA range:406-455
Subcellular Location
Cytoplasm, cytoskeleton. Nucleus. Mitochondrion . Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative st
Lipid-anchor. The myristoylated c-ABL protein is reported to be nuclear.
[Isoform IB]: Nucleus membrane
Lipid-anchor. The myristoylated c-ABL protein is reported to be nuclear.
[Isoform IB]: Nucleus membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Mouse
Human Gen
25/27
Observed Band
125(200kd BCR-ABL complex）
Other Name
ABL
ABL1
ABL2
ABLL
ARG
Abelson murine leukemia vira
Abelson murine leukemia viral oncogene homolog 1
Abelson tyrosine-protein kinase 1
Abelson tyrosine-protein kinase 2
JTK7
Proto-oncogene c-Abl
Tyrosine-protein kinase ABL1
p150
ABL1
ABL2
ABLL
ARG
Abelson murine leukemia vira
Abelson murine leukemia viral oncogene homolog 1
Abelson tyrosine-protein kinase 1
Abelson tyrosine-protein kinase 2
JTK7
Proto-oncogene c-Abl
Tyrosine-protein kinase ABL1
p150
Background
22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR
MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 dom
MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 dom