Información del producto
PDGFR-β (phospho Tyr1021) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human PDGFR beta around the phosphorylation site of Tyr1021. AA range:991-1040
Subcellular Location
Cell membrane
Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
5159
Observed Band
135-180kD
Other Name
Beta-type platelet-derived growth factor receptor
Beta platelet-derived growth factor receptor
CD140 antigen-like family member B
PDGF-R-beta
PDGFR
PDGFR-beta
PDGFR1
PDGFRB
Platelet-deri
Platelet-derived growth factor receptor beta
Beta platelet-derived growth factor receptor
CD140 antigen-like family member B
PDGF-R-beta
PDGFR
PDGFR-beta
PDGFR1
PDGFRB
Platelet-deri
Platelet-derived growth factor receptor beta
Background
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines
all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by Ref
all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by Ref