Información del producto
Neu (phospho Tyr1221/Y1222) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human Neu (phospho Tyr1221/Y1222)
Subcellular Location
Single-pass type I membrane protein. Early endosome . Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-
[Isoform 1]: Cell membrane
[Isoform 2]: Cytoplasm. Nucleus.
[Isoform 3]: Cytoplasm. Nucleus.
[Isoform 1]: Cell membrane
[Isoform 2]: Cytoplasm. Nucleus.
[Isoform 3]: Cytoplasm. Nucleus.
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Monkey
Mouse
Rat
Monkey
Mouse
Rat
Human Gen
2064
Observed Band
180kD
Other Name
CD antigen CD340
ERBB2
HER2
MLN 19
MLN19
Metastatic lymph node gene 19 protein
NEU
NGL
Proto-oncogene Neu
Proto-oncogene c-ErbB-2
Receptor tyrosine-protein kinase erbB-2
Tyrosine kinase-type cell surface receptor HER2
p185erbB2
ERBB2
HER2
MLN 19
MLN19
Metastatic lymph node gene 19 protein
NEU
NGL
Proto-oncogene Neu
Proto-oncogene c-ErbB-2
Receptor tyrosine-protein kinase erbB-2
Tyrosine kinase-type cell surface receptor HER2
p185erbB2
Background
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-boun