Información del producto
Akt1/3 (phospho Tyr437/434) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human AKT1/3 around the phosphorylation site of Tyr437/434. AA range:406-455
Subcellular Location
Cytoplasm . Nucleus . Cell membrane . Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane whe
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
207/10000
Observed Band
56kD
Other Name
AKT1
AKT3
PKB
PKB
PKBG
PKB alpha
Protein ki
Protein kinase Akt-3
Protein kinase B
Protein kinase B alpha
Proto-oncogene c-Akt
RAC
RAC-PK-alpha
RAC-alpha serine/threonine-protein kinase
RAC-gamma serine/threonine-protein kinase
AKT3
PKB
PKB
PKBG
PKB alpha
Protein ki
Protein kinase Akt-3
Protein kinase B
Protein kinase B alpha
Proto-oncogene c-Akt
RAC
RAC-PK-alpha
RAC-alpha serine/threonine-protein kinase
RAC-gamma serine/threonine-protein kinase
Background
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific,