Información del producto
p27 (phospho Thr187) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human p27 Kip1 around the phosphorylation site of Thr187. AA range:149-198
Subcellular Location
Nucleus. Cytoplasm. Endosome . Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10
this leads to lysosomal degradation (By similarity). .
this leads to lysosomal degradation (By similarity). .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
1027
Other Name
CDKN1B
Cyclin-dependent kinase inhibitor 1B
Cyclin-dependent kinase inhibitor p27
KIP1
p27Kip1
Cyclin-dependent kinase inhibitor 1B
Cyclin-dependent kinase inhibitor p27
KIP1
p27Kip1
Background
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle