Información del producto
MEK-1/2 (phospho Ser218/222) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human MEK1/2 around the phosphorylation site of Ser217. AA range:189-238
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Cytoplasm . Nucleus . Membrane
Peripheral membrane protein . Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis (PubMed:14737111). Membrane localization is probably regulated by its interaction with KSR1 (PubMed:10409742). .
Peripheral membrane protein . Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis (PubMed:14737111). Membrane localization is probably regulated by its interaction with KSR1 (PubMed:10409742). .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
5604/5605
Observed Band
48kD
Other Name
Dual specificity mitogen-activated protein k
Dual specificity mitogen-activated protein kinase kinase 1
ERK activator kinase 1
MAP2K1
MAP2K2
MAPK/ERK kinase 1
MAPKK 1
MAP kinase kinase 1
MEK 1
MEK1
MEK2
MKK1
MKK2
PRKMK1
PRKMK2
Dual specificity mitogen-activated protein kinase kinase 1
ERK activator kinase 1
MAP2K1
MAP2K2
MAPK/ERK kinase 1
MAPKK 1
MAP kinase kinase 1
MEK 1
MEK1
MEK2
MKK1
MKK2
PRKMK1
PRKMK2
Background
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration poin