Información del producto
Flk-1/VEGFR2 (phospho Tyr1214) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human VEGFR2 around the phosphorylation site of Tyr1214. AA range:1180-1229
Subcellular Location
Cell junction . Endoplasmic reticulum . Cell membrane . Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent
Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEG
[Isoform 1]: Cell membrane
[Isoform 2]: Secreted .
[Isoform 3]: Secreted.
Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEG
[Isoform 1]: Cell membrane
[Isoform 2]: Secreted .
[Isoform 3]: Secreted.
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
3791
Observed Band
152kD
Other Name
CD antigen CD309
FLK-1
FLK1
Fetal liver kinase 1
KDR
KDR
Kinase insert domain receptor
Protein-tyrosine kinase receptor flk-1
VEGFR-2
VEGFR2
Vascular endothelial growth factor receptor 2
FLK-1
FLK1
Fetal liver kinase 1
KDR
KDR
Kinase insert domain receptor
Protein-tyrosine kinase receptor flk-1
VEGFR-2
VEGFR2
Vascular endothelial growth factor receptor 2
Background
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions a