Información del producto
Ref-1 (Acetyl Lys6) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized Acetyl-peptide derived from human APE1 around the Acetylation site of Lys6. AA range:1-50
Subcellular Location
Nucleus. Nucleus, nucleolus. Nucleus speckle. Endoplasmic reticulum. Cytoplasm. Detected in the cytoplasm of B-cells stimulated to switch (By similarity). Colocalized with SIRT1 in the nucleus. Colocalized with YBX1 in nuclear speckles after genotoxic str
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
328
Observed Band
35kD
Other Name
APE
APE-1
APE1
APEN
APEX
APEX1
APEX nuclease
APX
AP endonuclease 1
Apurinic-apyrimidinic endonuclease 1
DNA-(apurinic or apyrimidinic site) lyase
HAP1
REF-1
REF1
Redox factor-1
APE-1
APE1
APEN
APEX
APEX1
APEX nuclease
APX
AP endonuclease 1
Apurinic-apyrimidinic endonuclease 1
DNA-(apurinic or apyrimidinic site) lyase
HAP1
REF-1
REF1
Redox factor-1
Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so
all encode the same protein. [provided by RefSeq, Jul 2008],
all encode the same protein. [provided by RefSeq, Jul 2008],