Información del producto
WWP2 antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IHC
Target
WWP2
Research Area
Epigenetics, Metabolism
Form
liquid
Recomended Dilution
IHC: 1:20-1:200
WB: 1:200-1:2000
WB: 1:200-1:2000
Type Clonality
polyclonal
Immunogen
WW domain containing E3 ubiquitin protein ligase 2
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
NEDD4-like E3 ubiquitin-protein ligase WWP2|Atrophin-1-interacting protein 2 (AIP2)|HECT-type E3 ubiquitin transferase WWP2|WW domain-containing protein 2|WWP2
Host
Rabbit
UniProt ID
O00308
Gene ID
11060
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse
Observed MW
120 kDa
Background
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes i
in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2
in embryonic stem cells(ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation
the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2
in embryonic stem cells(ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation
the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.