Información del producto
VRK2 antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IP
Target
VRK2
Research Area
Metabolism
Form
liquid
Recomended Dilution
IP: 1:200-1:2000
WB: 1:500-1:5000
WB: 1:500-1:5000
Type Clonality
polyclonal
Immunogen
vaccinia related kinase 2
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
Serine/threonine-protein kinase VRK2|Vaccinia-related kinase 2|VRK2
Host
Rabbit
UniProt ID
Q86Y07
Gene ID
7444
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse, Rat
Observed MW
67 kDa
Background
Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.
Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta(IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen
Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta(IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen