Información del producto
FOXP1 antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IHC
Target
FOXP1
Research Area
Signal Transduction, Metabolism, Developmental biology, Neuroscience, Stem Cells
Form
liquid
Recomended Dilution
IHC: 1:20-1:200
WB: 1:500-1:2000
WB: 1:500-1:2000
Type Clonality
polyclonal
Immunogen
forkhead box P1
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
Forkhead box protein P1|Mac-1-regulated forkhead (MFH)|FOXP1
Host
Rabbit
UniProt ID
Q9H334
Gene ID
27086
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse, Rat
Observed MW
50 kDa, 60-65 kDa, 85 kDa
Background
Isoform 8: Involved in transcriptional regulation in embryonic stem cells(ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding speci
Transcriptional repressor(PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential(By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts
may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintainance of hair follicle stem cell quiescence
repression of CSF1R in monocytes seems to involve NCOR2 as corepressor(PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis
the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of t
the function probably involves regulation of FGF18(By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis(PubMed:25267198).
the role in neovascularization seems to implicate suppression of SEMA5B(PubMed:24023716). Can negatively regulate androgen receptor signaling(PubMed:18640093).
Transcriptional repressor(PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential(By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts
may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintainance of hair follicle stem cell quiescence
repression of CSF1R in monocytes seems to involve NCOR2 as corepressor(PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis
the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of t
the function probably involves regulation of FGF18(By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis(PubMed:25267198).
the role in neovascularization seems to implicate suppression of SEMA5B(PubMed:24023716). Can negatively regulate androgen receptor signaling(PubMed:18640093).