Información del producto
FBXW7 antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IHC
Target
FBXW7
Research Area
Immunology, Cardiovascular, Metabolism
Form
liquid
Recomended Dilution
IHC: 1:50 - 1:200
WB: 1:500 - 1:2000
WB: 1:500 - 1:2000
Type Clonality
polyclonal
Immunogen
F-box and WD repeat domain containing 7
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
F-box/WD repeat-containing protein 7|Archipelago homolog (hAgo)|F-box and WD-40 domain-containing protein 7|F-box protein FBX30|SEL-10|hCdc4|FBXW7|FBW7|FBX30|SEL10
Host
Rabbit
UniProt ID
Q969H0
Gene ID
55294
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse, Rat
Observed MW
80 kDa
Background
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), w
in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, im
s potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, im
s potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.