Información del producto
BRCC3 antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IHC
Target
BRCC3
Research Area
Signal Transduction, Cancer
Form
liquid
Recomended Dilution
IHC: 1:20-1:200
WB: 1:500-1:2000
WB: 1:500-1:2000
Type Clonality
polyclonal
Immunogen
BRCA1/BRCA2-containing complex, subunit 3
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
Lys-63-specific deubiquitinase BRCC36|BRCA1-A complex subunit BRCC36|BRCA1/BRCA2-containing complex subunit 3|BRCA1/BRCA2-containing complex subunit 36|BRISC complex subunit BRCC36|BRCC3|BRCC36|C6.1A|CXorf53
Host
Rabbit
UniProt ID
P46736
Gene ID
79184
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse, Rat, Monkey
Observed MW
65-70 kDa
Background
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains(PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a com
deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression(PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide(LPS) via its role in IFNAR1 deubiquitination(PubMed:24075985).
deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression(PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide(LPS) via its role in IFNAR1 deubiquitination(PubMed:24075985).