Información del producto
AXL antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IP, FC
Target
AXL
Research Area
Cancer, Immunology, Signal Transduction, Metabolism
Form
liquid
Recomended Dilution
IP: 1:500-1:2000
WB: 1:500-1:3000
WB: 1:500-1:3000
Type Clonality
polyclonal
Immunogen
AXL receptor tyrosine kinase
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
Tyrosine-protein kinase receptor UFO|AXL oncogene|AXL|UFO
Host
Rabbit
UniProt ID
P30530
Gene ID
558
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse, Rat
Observed MW
140 kDa
Background
(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope(PubMed:22156524, PubMed:22673088, PubMed:25277499, PubMed:21501828). Ac
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differenti
but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differenti
but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/