Información del producto
AKT1 antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, IHC, WB, IF
Target
AKT1
Research Area
Metabolism, Cardiovascular, Immunology, Developmental biology, Neuroscience, Stem Cells
Form
liquid
Recomended Dilution
IF: 1:10-1:100
IHC: 1:20-1:200
WB: 1:200-1:2000
IHC: 1:20-1:200
WB: 1:200-1:2000
Type Clonality
polyclonal
Immunogen
v-akt murine thymoma viral oncogene homolog 1
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
RAC-alpha serine/threonine-protein kinase|Protein kinase B (PKB)|Protein kinase B alpha (PKB alpha)|Proto-oncogene c-Akt|RAC-PK-alpha|AKT1|PKB|RAC
Host
Rabbit
UniProt ID
P31749
Gene ID
207
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human
Observed MW
62 kDa
Background
AKT1 is one of 3 closely related serine/threonine-protein kinases(AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine an
AKT1-specific substrates have been recently identified, including palladin(PALLD), which phosphorylation modulates cytoskeletal organization and cell motility
and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby
prohibitin(PHB), playing an important role in cell metabolism and proliferation
AKT1-specific substrates have been recently identified, including palladin(PALLD), which phosphorylation modulates cytoskeletal organization and cell motility
and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby
prohibitin(PHB), playing an important role in cell metabolism and proliferation