Información del producto
ACO1 antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IHC
Target
ACO1
Research Area
Metabolism
Form
liquid
Recomended Dilution
IHC: 1:50 - 1:100
WB: 1:500 - 1:2000
WB: 1:500 - 1:2000
Type Clonality
polyclonal
Immunogen
aconitase 1, soluble
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
Cytoplasmic aconitate hydratase (Aconitase)|Citrate hydro-lyase|Ferritin repressor protein|Iron regulatory protein 1 (IRP1)|Iron-responsive element-binding protein 1 (IRE-BP 1)|ACO1|IREB1
Host
Rabbit
UniProt ID
P21399
Gene ID
48
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse, Rat
Observed MW
120 kDa
Background
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4F
UTR of ferritin mRNA, and in the 3&apos
UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified a
UTR of ferritin mRNA, and in the 3&apos
UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified a