Storage Conditions
-20°C/1 year
Applications
ELISA
WB
Concentration
1 mg/ml
Recomended Dilution
WB 1:500-2000 ELISA 1:5000-20000
Type Clonality
Polyclonal
Immunogen
Synthesized peptide derived from part region of human protein
Subcellular Location
Nucleus, PML body. Cytoplasm. The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Human Gen
4778
Observed Band
41kD
Background
function:Required for activity at the locus control region (LCR) upstream of the globin gene complexes. Requires p18 NF-E2 for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production: globin synthesis, heme synthesis, and the p
leading to activate transcription of the beta-globin locus (By similarity). Heterodimer of p45 NF-E2 and p18 NF-E2. Forms high affinity heterodimer with MAFG
the interaction promotes erythropoiesis.,tissue specificity:Expressed in hematopoietic cells and also in colon and testis.,