Información del producto
WRN (phospho Ser1141) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
WB
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Werner Syndrome Helicase around the phosphorylation site of Ser1141. AA range:1107-1156
Subcellular Location
Nucleus, nucleolus . Nucleus . Nucleus, nucleoplasm . Chromosome . Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation (PubMed:21639834). Localizes to DNA damage sites (PubMed:
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
7486
Observed Band
162kD
Other Name
DNA helicase
Exonuclease WRN
RECQ3
RECQL2
RecQ-like type 3
RecQ3
RecQ protein-like 2
WRN
Werner syndrome ATP-dependent helicase
Exonuclease WRN
RECQ3
RECQL2
RecQ-like type 3
RecQ3
RecQ protein-like 2
WRN
Werner syndrome ATP-dependent helicase
Background
Werner syndrome RecQ like helicase(WRN) Homo sapiens This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcripti