Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
Synthesized peptide derived from SP-100 . at AA range: 250-330
Subcellular Location
Nucleus. Nucleus, PML body . Cytoplasm. Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon-dependent. Accumulates in the cytoplasm upon FAS activation.
[Isoform Sp100-C]: Nucleus . Forms a reticulate or track-like nuclear pattern with denser concentrations at the nuclear lamina and surrounding the nucleoli, a pattern reminiscent of heterochromatin-rich regions according to PubMed:11313457.
[Isoform Sp100-C]: Nucleus . Forms a reticulate or track-like nuclear pattern with denser concentrations at the nuclear lamina and surrounding the nucleoli, a pattern reminiscent of heterochromatin-rich regions according to PubMed:11313457.
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
6672
Observed Band
100kD
Other Name
Lysp100b
Nuclear autoantigen Sp-100
Nuclear dot-associated Sp100 protein
SP100
Speckled 100 kDa
Nuclear autoantigen Sp-100
Nuclear dot-associated Sp100 protein
SP100
Speckled 100 kDa
Background
This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded prot
one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011],
one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011],