Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
WB
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human ITCH. AA range:386-435
Subcellular Location
Cell membrane
Cytoplasmic side . Cytoplasm . Nucleus . Early endosome membrane
Cytoplasmic side . Endosome membrane
Cytoplasmic side . May be recruited to exosomes by NDFIP1 (PubMed:18819914). Localizes to plasma membrane upon CXCL12 stimulation where it co-localizes with CXCL4 (PubMed:14602072). Localization to early endosomes is increased upon CXCL12 stimulation wher
Peripheral membrane protein
Peripheral membrane protein
Peripheral membrane protein
Cytoplasmic side . Cytoplasm . Nucleus . Early endosome membrane
Cytoplasmic side . Endosome membrane
Cytoplasmic side . May be recruited to exosomes by NDFIP1 (PubMed:18819914). Localizes to plasma membrane upon CXCL12 stimulation where it co-localizes with CXCL4 (PubMed:14602072). Localization to early endosomes is increased upon CXCL12 stimulation wher
Peripheral membrane protein
Peripheral membrane protein
Peripheral membrane protein
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Mouse
Human Gen
83737
Observed Band
103kD
Other Name
AIP4
Atrophin-1-interacting protein 4
E3 ubiquitin-protein ligase Itchy homolog
ITCH
Itch
NAPP1
NFE2-associated polypeptide 1
Atrophin-1-interacting protein 4
E3 ubiquitin-protein ligase Itchy homolog
ITCH
Itch
NAPP1
NFE2-associated polypeptide 1
Background
itchy E3 ubiquitin protein ligase(ITCH) Homo sapiens This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, th