Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Smad4. AA range:21-70
Subcellular Location
Cytoplasm . Nucleus . Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R-SMAD (PubMed:15799969). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236). .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Monkey
Mouse
Rat
Monkey
Mouse
Rat
Human Gen
4089
Observed Band
60kD
Other Name
DPC4
Deletion target in pancreatic carcinoma 4
MADH4
MAD homolog 4
Mothers against DPP homolog 4
Mothers against decapentaplegic homolog 4
SMAD4
SMAD 4
SMAD family member 4
Smad4
hSMAD4
Deletion target in pancreatic carcinoma 4
MADH4
MAD homolog 4
Mothers against DPP homolog 4
Mothers against decapentaplegic homolog 4
SMAD4
SMAD 4
SMAD family member 4
Smad4
hSMAD4
Background
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric co