Información del producto
Rac GAP1 (phospho Ser387) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human GTPase Activating Protein around the phosphorylation site of Ser387. AA range:353-402
Subcellular Location
Cytoplasmic side. Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and the acrosome (By similarity). During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, i
Nucleus . Cytoplasm. Cytoplasm, cytoskeleton, spindle . Cytoplasmic vesicle, secretory vesicle, acrosome. Cleavage furrow. Midbody, Midbody ring . Cell membrane
Peripheral membrane protein
Nucleus . Cytoplasm. Cytoplasm, cytoskeleton, spindle . Cytoplasmic vesicle, secretory vesicle, acrosome. Cleavage furrow. Midbody, Midbody ring . Cell membrane
Peripheral membrane protein
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Monkey
Mouse
Rat
Monkey
Mouse
Rat
Human Gen
29127
Observed Band
72kD
Other Name
CYK4
HsCYK-4
KIAA1478
MGCRACGAP
Male germ cell RacGap
MgcRacGAP
Protein CYK4 homolg
RACGAP1
Rac GTPase-activating protein 1
HsCYK-4
KIAA1478
MGCRACGAP
Male germ cell RacGap
MgcRacGAP
Protein CYK4 homolg
RACGAP1
Rac GTPase-activating protein 1
Background
This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This pro