Información del producto
Akt (phospho Tyr315) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human AKT1/2/3 around the phosphorylation site of Tyr315/316/312. AA range:281-330
Subcellular Location
Cytoplasm . Nucleus . Cell membrane . Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane whe
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
207/208/10000
Observed Band
56kD
Other Name
AKT1
AKT2
PKB
PKB
PKB alpha
Protein kinase Akt-2
Protein kinase B
Protein kinase B
Protein kinase B alpha
Proto-oncogene c-Akt
RAC
RAC-PK-alpha
RAC-alpha serine/threonine-protein kinase
RAC-beta serine/threonine-protein kinase
AKT2
PKB
PKB
PKB alpha
Protein kinase Akt-2
Protein kinase B
Protein kinase B
Protein kinase B alpha
Proto-oncogene c-Akt
RAC
RAC-PK-alpha
RAC-alpha serine/threonine-protein kinase
RAC-beta serine/threonine-protein kinase
Background
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific,