Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human MUC1. AA range:1021-1070
Subcellular Location
Apical cell membrane
Single-pass type I membrane protein . Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long fi
[Isoform 5]: Secreted.
[Isoform 9]: Secreted.
[Isoform Y]: Secreted.
[Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus. On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin
Single-pass type I membrane protein . Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long fi
[Isoform 5]: Secreted.
[Isoform 9]: Secreted.
[Isoform Y]: Secreted.
[Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus. On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
4582
Observed Band
122kD
Other Name
Breast carcinoma-associated antigen DF3
CD227
Carcinoma-associated mucin
EMA
Episialin
H23AG
KL-6
Krebs von den Lungen-6
MUC-1
MUC1
Mucin-1
PEM
PEMT
PUM
PUM
Peanut-reactive urinary mucin
Polymorphic epithelial mucin
Tumor-associated epithelial membrane antigen
Tumor-associated mucin
CD227
Carcinoma-associated mucin
EMA
Episialin
H23AG
KL-6
Krebs von den Lungen-6
MUC-1
MUC1
Mucin-1
PEM
PEMT
PUM
PUM
Peanut-reactive urinary mucin
Polymorphic epithelial mucin
Tumor-associated epithelial membrane antigen
Tumor-associated mucin
Background
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular