Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
WB
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from the N-terminal region of human GHR. AA range:21-70
Subcellular Location
Cell membrane
Single-pass type I membrane protein. On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway. .
Single-pass type I membrane protein. Remains fixed to the cell membrane and is not internalized.
[Growth hormone-binding protein]: Secreted. Complexed to a substantial fraction of circulating GH. .
[Isoform 2]: Cell membrane
Single-pass type I membrane protein. On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway. .
Single-pass type I membrane protein. Remains fixed to the cell membrane and is not internalized.
[Growth hormone-binding protein]: Secreted. Complexed to a substantial fraction of circulating GH. .
[Isoform 2]: Cell membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
2690
Observed Band
140kD
Other Name
GHR
GH receptor
Growth hormone receptor
Somatotropin receptor
GH receptor
Growth hormone receptor
Somatotropin receptor
Background
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal tran