Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Trk B. AA range:671-720
Subcellular Location
Cell membrane
Single-pass type I membrane protein . Early endosome membrane . Cell projection, axon . Cell projection, dendrite . Cytoplasm, perinuclear region . Cell junction, synapse, postsynaptic density . Internalized to endosomes upon ligand-binding. .
Single-pass type I membrane protein . Endosome membrane
Single-pass type I membrane protein . Early endosome membrane . Cell projection, axon . Cell projection, dendrite . Cytoplasm, perinuclear region . Cell junction, synapse, postsynaptic density . Internalized to endosomes upon ligand-binding. .
Single-pass type I membrane protein . Endosome membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
4915
Observed Band
145kD
Other Name
BDNF/NT-3 growth factors receptor
GP145-TrkB
NTRK2
Neurotrophic tyrosine kinase receptor type 2
TRKB
Trk-B
TrkB tyrosine kinase
Tropomyosin-related kinase B
GP145-TrkB
NTRK2
Neurotrophic tyrosine kinase receptor type 2
TRKB
Trk-B
TrkB tyrosine kinase
Tropomyosin-related kinase B
Background
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to