Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human PKR. AA range:413-462
Subcellular Location
Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Nuclear localization is elevated in acute leukemia, myelodysplastic syndrome (MDS), melanoma, breast, colon, prostate and lung cancer patient samples or cell lines as well as neurocytes from advanced C
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
5610
Observed Band
74kD
Other Name
EIF2AK2
Eukaryotic translation initiation factor 2-alpha kinase 2
Interferon-induced
Interferon-inducible RNA-dependent protein kinase
P1/eIF-2A protein k
PKR
PRKR
double-stranded RNA-activated protein kinase
eIF-2A protein kinase 2
Eukaryotic translation initiation factor 2-alpha kinase 2
Interferon-induced
Interferon-inducible RNA-dependent protein kinase
P1/eIF-2A protein k
PKR
PRKR
double-stranded RNA-activated protein kinase
eIF-2A protein kinase 2
Background
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits