Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Parkin. AA range:101-150
Subcellular Location
Cytoplasm, cytosol . Nucleus . Endoplasmic reticulum . Mitochondrion . Mitochondrion outer membrane . Cell projection, neuron projection . Cell junction, synapse, postsynaptic density . Cell junction, synapse, presynapse . Mainly localizes in the cytosol
recruitment to mitochondria is PINK1-dependent (PubMed:24898855, PubMed:18957282, PubMed:19966284, PubMed:23620051). Mitochondrial localization also gradually increases with cellular growth (PubMed:22082830). .
recruitment to mitochondria is PINK1-dependent (PubMed:24898855, PubMed:18957282, PubMed:19966284, PubMed:23620051). Mitochondrial localization also gradually increases with cellular growth (PubMed:22082830). .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Chicken
Human
Mouse
Rat
Human
Mouse
Rat
Human Gen
5071
Observed Band
55kD
Other Name
E3 ubiquitin-protein ligase parkin
PARK2
PRKN
Parkinson disease protein 2
Parkinson juvenile disease protein 2
PARK2
PRKN
Parkinson disease protein 2
Parkinson juvenile disease protein 2
Background
The precise function of this gene is unknown
however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive ju
however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive ju