Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human p14 ARF. AA range:71-120
Subcellular Location
Nucleus, nucleolus . Nucleus, nucleoplasm .
[Isoform smARF]: Mitochondrion .
[Isoform smARF]: Mitochondrion .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
1029
Observed Band
18kD
Other Name
CDKN2
CDKN2A
Cyclin-dependent kinase inhibitor 2A
MLM
isoform 4
p14ARF
p19ARF
CDKN2A
Cyclin-dependent kinase inhibitor 2A
MLM
isoform 4
p14ARF
p19ARF
Background
CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors
this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interac
this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interac