Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human FAS ligand. AA range:101-150
Subcellular Location
Cell membrane
Single-pass type II membrane protein . Cytoplasmic vesicle lumen . Lysosome lumen . Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290). Colocalizes with the SPPL2A protea
[FasL intracellular domain]: Nucleus . The FasL ICD cytoplasmic form is translocated into the nucleus. .
[Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted . May be released into the extracellular fluid by cleavage from the cell surface. .
Single-pass type II membrane protein . Cytoplasmic vesicle lumen . Lysosome lumen . Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290). Colocalizes with the SPPL2A protea
[FasL intracellular domain]: Nucleus . The FasL ICD cytoplasmic form is translocated into the nucleus. .
[Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted . May be released into the extracellular fluid by cleavage from the cell surface. .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Pig
Mouse
Pig
Human Gen
356
Observed Band
33kD
Other Name
APT1LG1
APTL
Apoptosis antigen ligand
CD95 ligand
CD95-L
CD95L
CD antigen CD178
FASL
FASLG
FasL
Fas antigen ligand
Fas ligand
TNFSF6
Tumor necrosis factor ligand superfamily member 6
APTL
Apoptosis antigen ligand
CD95 ligand
CD95-L
CD95L
CD antigen CD178
FASL
FASLG
FasL
Fas antigen ligand
Fas ligand
TNFSF6
Tumor necrosis factor ligand superfamily member 6
Background
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation,