Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human CLU. AA range:400-449
Subcellular Location
Cytoplasmic side . Cytoplasm, cytosol . Microsome . Endoplasmic reticulum . Mitochondrion . Mitochondrion membrane . Cytoplasm, perinuclear region . Cytoplasmic vesicle, secretory vesicle, chromaffin granule . Secreted isoforms can retrotranslocate from t
Nucleus . Cytoplasm . Mitochondrion membrane
Peripheral membrane protein
[Isoform 1]: Secreted . Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. .
[Isoform 4]: Cytoplasm . Keeps cytoplasmic localization in stressed and unstressed cell. .
[Isoform 6]: Cytoplasm . Keeps cytoplasmic localization in stressed and unstressed cell. .
Nucleus . Cytoplasm . Mitochondrion membrane
Peripheral membrane protein
[Isoform 1]: Secreted . Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. .
[Isoform 4]: Cytoplasm . Keeps cytoplasmic localization in stressed and unstressed cell. .
[Isoform 6]: Cytoplasm . Keeps cytoplasmic localization in stressed and unstressed cell. .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
1191
Observed Band
52kD
Other Name
40
AAG4
APOJ
Aging-associated gene 4 protein
Apo-J
Apolipoprotein J
CLI
CLI
CLU
Clusterin
Complement-associated protein SP-40
Complement cytolysis inhibitor
KUB1
Ku70-binding protein 1
NA1/NA2
Testosterone-repressed prostate m
AAG4
APOJ
Aging-associated gene 4 protein
Apo-J
Apolipoprotein J
CLI
CLI
CLU
Clusterin
Complement-associated protein SP-40
Complement cytolysis inhibitor
KUB1
Ku70-binding protein 1
NA1/NA2
Testosterone-repressed prostate m
Background
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegen