Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human CEP55. AA range:81-130
Subcellular Location
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cleavage furrow . Midbody, Midbody ring . Present at the centrosomes at interphase. A small po
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
55165
Observed Band
54kD
Other Name
C10orf3
CEP55
Centrosomal protein of 55 kDa
Cep55
URCC6
Up-regulated in colon cancer 6
CEP55
Centrosomal protein of 55 kDa
Cep55
URCC6
Up-regulated in colon cancer 6
Background
CEP55 binds PDCD6IP in a 2:1 stoechiometry
PDCD6IP competes with TSG101 for the same binding site. Interacts with TSG101
TSG101 competes with PDCD6IP for the same binding site
function:Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.,PTM:There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the
interaction is required for cytokinesis but not for viral budding. Interacts with FAM125A, VPS37B, VPS37C and VPS28.,tissue specificity:Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal t
the interaction is direct
the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT
the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PDCD6IP
PDCD6IP competes with TSG101 for the same binding site. Interacts with TSG101
TSG101 competes with PDCD6IP for the same binding site
function:Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.,PTM:There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the
interaction is required for cytokinesis but not for viral budding. Interacts with FAM125A, VPS37B, VPS37C and VPS28.,tissue specificity:Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal t
the interaction is direct
the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT
the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PDCD6IP