Información del producto
Cot (phospho Thr290) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human COT around the phosphorylation site of Thr290. AA range:256-305
Subcellular Location
Cytoplasm .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
1326
Observed Band
60kD
Other Name
COT
Cancer Osaka thyroid oncogene
ESTF
MAP3K8
Mitogen-activated protein kinase kinase kinase 8
Proto-oncogene c-Cot
Serine/threonine-protein kinase cot
TPL-2
Tumor progression locus 2
Cancer Osaka thyroid oncogene
ESTF
MAP3K8
Mitogen-activated protein kinase kinase kinase 8
Proto-oncogene c-Cot
Serine/threonine-protein kinase cot
TPL-2
Tumor progression locus 2
Background
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases,