Información del producto
Btk (phospho Tyr223) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
WB
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human BTK around the phosphorylation site of Tyr223. AA range:188-237
Subcellular Location
Cytoplasm. Cell membrane
Peripheral membrane protein. Nucleus. In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the
Peripheral membrane protein. Nucleus. In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
695
Observed Band
80kD
Other Name
AGMX1
ATK
ATK
Agammaglobulinaemia tyrosine kinase
B-cell progenitor kinase
BPK
BPK
BTK
Bruton tyrosine kinase
Tyrosine-protein kinase BTK
ATK
ATK
Agammaglobulinaemia tyrosine kinase
B-cell progenitor kinase
BPK
BPK
BTK
Bruton tyrosine kinase
Tyrosine-protein kinase BTK
Background
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a