Información del producto
Cleaved-Caspase-4 p20 (Q81) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Caspase 4. AA range:62-111
Subcellular Location
Cytoplasm, cytosol . Endoplasmic reticulum membrane
Cytoplasmic side . Mitochondrion . Inflammasome . Secreted . Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UV
Peripheral membrane protein
Cytoplasmic side . Mitochondrion . Inflammasome . Secreted . Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UV
Peripheral membrane protein
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Human Gen
837
Observed Band
43+22kD
Other Name
CASP-4
CASP4
Caspase-4
ICE(rel)-II
ICH2
Protease ICH-2
Protease TX
CASP4
Caspase-4
ICE(rel)-II
ICH2
Protease ICH-2
Protease TX
Background
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prod