Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Applications
WB, IHC
Concentration
1mg/mL
Recomended Dilution
WB 1:1,000-2,000 IHC 1:100-200
Type Clonality
Polyclonal
Immunogen
Recombinant Protein
Subcellular Location
Secreted,Cell membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human, Rat, Mouse
Human Gen
7124
Observed Band
17,25kDa
Other Name
APC1 antibody, DIF antibody, TNFSF2 antibody, Tumor necrosis factor alpha antibody
Background
TNF-α, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II membrane protein. It can cause cytolysis of certain tumor cell lines
it can stimulate cell proliferation and induce cell differentiation under certain conditions..
it is a potent pyrogen, causing fever by direct action or by stimulation of interlerukin-1 secretion
it is involved in the induction of cachexia